2021 Scientific Program
Sunday, August 1, 2021
The CGC 2021 Virtual Annual Meeting will be presented in the eastern daylight times (EDT) shown below.
After each presentation, recordings will be available on the virtual meeting platform for those registrants in different time zones, and will be posted later on the CGC website for on demand access for CGC members.
To download the scientific program, please click here.
Opening of the 12th Annual Cancer Genomics Consortium
11:30 AM
Welcome
Patricia M. Miron, UMass Memorial Medical Center
11:35 AM - 12:35 PM
Keynote Presentation
Deciphering oncohistone pathogenesis in cancer
Nada Jabado, McGill University
Introduction: Patricia M. Miron, UMass Memorial Medical Center
Speaker Q & A
12:35 - 1:20 PM
Diamond Vendor Showcase: Illumina
(No CME available)
DNA Methylation, CNV Analysis, and Case Studies
Andreas von Deimling, University Clinic Heidelberg and DKFZ
Eric Vail, Cedars-Sinai
David Solomon, University of California San Francisco
Speaker Q & A
1:20 - 1:25 PM
Break: Announcements
1:25 - 2:25 PM
Session 1: Brain Tumors - Molecular Landscape and Emerging Targets
Moderators:
Jaclyn Biegel, Children's Hospital Los Angeles
Vera Paulson, University of Washington
Clinicopathologic analysis of gliomas harboring ROS1 gene arrangements
Xinyan Lu, Northwestern University Feinberg School of Medicine
TERT and MGMT RNA sequencing gene expression correlation with mutational/methylation promoter status in brain tumors
Cristiane Ida, Mayo Clinic
Optical genome mapping reveals novel structural variants in pediatric high grade gliomas
Miriam Bornhorst, Children's National Hospital
Glioblastomas with MAPK pathway alterations show low grade histologic features and present novel therapeutic targets
David Meredith, Brigham and Women's Hospital
Session Q & A
2:25 - 2:50 PM
Platinum Vendor Showcase: Qiagen
(No CME available)
Homologous recombination repair (HRR) and deficiency (HRD): The role of DNA damage repair (DRR)
Vikas Gupta and Raed Samara, Qiagen
Gold Vendor Showcase: BioDot
(No CME available)
BioDot CellWriter
Matt Sergent, BioDot
2:55 - 3:00 PM
Break: Announcements
Workshops
Additional Information available online.
There is an additional registration fee to attend the workshops.
CGC Workshop
Visualization and interpretation tools/resources for structural genomic variants
Moderator:
Deborah Ritter, Baylor College of Medicine
Speakers:
Debyani Chakravarty, Memorial Sloan Kettering Cancer Center
Jianjiong Gao, Memorial Sloan Kettering Cancer Center
Jason Saliba, Washington University in St. Louis
Ahmet Zehir, Memorial Sloan Kettering Cancer Center
Break: Announcements
CGC Workshop
Case-based discussion of updates in cytogenetic and molecular nomenclature, interpretation and reporting standards, and interpretation resources for cancer variants
Moderator:
Gordana Raca, Children's Hospital Los Angeles
Speakers:
Jean McGowan-Jordan, CHEO Genetics Diagnostic Laboratory/University of Ottawa
Beth Pitel, Mayo Clinic
Teresa Smolarek, Cincinnati Children’s Hospital Medical Center
Gordana Raca, Children’s Hospital Los Angeles
Svetlana Yatsenko, University of Pittsburgh Medical Center
Ravindra Kohle, Augusta University
Early Career/New Director Event
Monday, August 2, 2021
10:00 - 10:10 AM
Presidential Address
Yassmine Akkari, Legacy Health
Session 2: New Strides in Technology
Moderators:
Fabiola Quintero-Rivero, University of California Irvine
Cinthya Zepeda, ARUP
Clinical laboratory validation of TCR-seq for detection of clonality
Jane Houldsworth, Icahn School of Medicine at Mount Sinai
Emerging clinically-relevant applications of ultra-sensitive mutation detection
Lei Wei, Roswell Park Comprehensive Cancer Center
Adoption of optical genome mapping in clinical cancer cytogenetic laboratory: A stepwise approach
Victoria Stinnett, The Johns Hopkins University
Rapid clinical BRAF V600 mutation testing using Idylla Platform
Meenakshi Mehrotra, Icahn School of Medicine at Mount Sinai
Session Q & A
Gold Vendor Showcase: FujiFilm Irvine Scientific
(No CME available)
Cell culture media specialists: Providing solutions for cytogenetics in clinical and research applications
Shaun Waters, FujiFilm Irvine Scientific
Break: Announcements
Keynote Presentation
Global views of cell lineage in metastasis and development
Jay Shendure, University of Washington
Introduction: Cinthya Zepeda, ARUP
Speaker Q & A
Diamond Vendor Showcase: Bionano Genomics
(No CME available)
Ushering in a New Era for Cytogenomics Based on Optical Genome Mapping
Alka Chaubey, Bionano Genomics
Panelists:
Ravindra Kolhe, Augusta University
Adrian Lee, University of Pittsburgh Medical Center
Alan Lennon, Pathgroup
Lunch Break / Exhibit Hall Open
Invited Speaker
The next generation of cytogenetics and molecular genetics in leukemia diagnostics
Torsten Haferlach, Munich Leukemia Laboratory
Introduction: Rashmi Kanagal-Shamanna, MD Anderson
Speaker Q & A
Gold Vendor Showcase: ADS Biotec
(No CME available)
Enabling Seamless Automation In Cytogenetics
John McCloskey, ADS Biotec
Session 3: New Molecular Insights into Myeloid Hematologic Malignancies
Moderators:
Gordana Raca, Children's Hospital Los Angeles
Lisa Lansdon, Children's Mercy Hospital
ETV6-PDGFRA fusions detected by FISH in acute myeloid leukemia with translocation t(4;12)(q12;p13) are false-positive
Sarah Mueller, Massachusetts General Hospital
Tied for First Place Trainee Abstract Award
SNP microarray analysis of over 7,500 myeloid patients: Implications, importance and suggestions for standard of care
Stuart Schwartz, Laboratory Corporation of America
Optical genome mapping for chromosomal structural variants analysis in hematological malignancies
Rashmi Kanagal-Shamanna, MD Anderson Cancer Center
Session Q & A
Platinum Vendor Showcase: SOPHiA Genetics
(No CME available)
The SOPHiA DDMTM Platform: Deep dive on how we support solid tumor detection
Emily Paul, Mikhail Pertziger, and Marián Novak, SOPHiA Genetics
Exhibit Hall Open
Session 4: Integrating Genomics into Constitutional Analysis
Moderators:
Patricia Miron, UMass Memorial Medical Center
Rebecca Smith, Genetics Associates, Inc.
Cancer cytogenomic array analysis reveals origin of ovarian teratoma and reproductive lessons learned from it
Lina Shao, University of Michigan
Next-generation cytogenetics: Proposal for a cost-effective approach for comprehensive testing of prenatal cases
Nikhil Sahajpal, Augusta University
Deletions resulting in Brachydactyly Mental Retardation Syndrome (BDMR): Multiple contributing regions in distal 2q37?
Aiko Otsubo, Indiana University
Gold Vendor Showcase: Global Alliance for Genomics & Health (GA4GH)
(No CME available)
Presenting the Global Alliance for Genomics & Health (GA4GH)
Panel-Based Discussion: Navigating the evolution of cytogenetics
Yassmine Akkari, Legacy Health
Linda Baughn, Mayo Clinic
P. Alan Lennon, PathGroup
Karen Rabin, Texas Children's Cancer Center, Baylor College of Medicine
Q & A with Speakers
Tuesday, August 3, 2021
10:00 - 11:00 AM
Session 5: Data Base Curation and Mining
Moderators:
Kilannin Krysiak, Washington University School of Medicine
Beth Pitel, Mayo Clinic
Standard procedure for the curation and maintenance of cancer-specific gene lists
Beth A. Pitel, Mayo Clinic
First Place Technologist Abstract Award
Enhancement of pediatric cancer curation and representation through expert-guided data mining and ontology refinement
Jason Saliba, Washington University School of Medicine
Multi-consortia initiative to standardize the representation and curation of oncogenic fusions
Alex Wagner, Nationwide Children's Hospital
Progenetix - An open reference resource for copy number variation data in cancer
Qingyao Huang, Universität Zürich
Session Q & A
Gold Vendor Showcase: The Jackson Laboratory
(No CME available)
JAX Clinical Knowledgebase (CKB)
Cara Statz, The Jackson Laboratory
11:05 - 11:50 AM
Invited Speaker
AI applications to drive precision oncology clinical trials
Subha Madhavan, AstraZeneca
Introduction: Obi Griffith, Washington University
Speaker Q & A
11:50 AM - 12:35 PM
Diamond Vendor Showcase: Agilent Technologies
(No CME available)
One workflow - endless options: NGS workflow solutions
Brigette Brown-Kipphut, Agilent Technologies
K.C. Varva, Agilent Technologies
Roundtable Breakout Sessions – Topic list available online
Please make your selection during registration – only 16 spaces are available in each discussion topic
1:40 - 2:15 PM
Lunch Break / Exhibit Hall Open
Keynote Presentation
Towards population genomic screening for cancer susceptibility
Leslie G. Biesecker, National Human Genome Research Institute
Introduction: P. Alan Lennon, PathGroup
Speaker Q & A
Gold Vendor Showcase: Geneoscopy
(No CME available)
Presenting Geneoscopy
Erica Barnell, Geneoscopy
Session 6: Genetic Spectrum of Vascular Anomalies and Overgrowth Syndromes
Moderators:
Min Fang, Fred Hutchinson Cancer Research Center
Alaa Koleilat, Mayo Clinic
Genomic structural variations in lymphatic anomalies
Thuy Phung, University of South Alabama
Diagnostic utility and lessons learned from deep sequencing vascular malformations
Candace Myers, Seattle Children's Hospital
Co-existence of two activating variants in somatic overgrowth & vascular anomalies: 7 years' findings at a single center
Yang Cao, Washington University School of Medicine
Session Q & A
4:05 - 4:30 PM
Platinum Vendor Showcase: Natera
(No CME available)
Informed by the tumor: The power of a personalized ctDNA Assay for Treatment Monitoring in HER2
Angel Rodriguez and John Simmons, Natera
4:30 - 5:30 PM
Exhibit Hall Open
Session 7: Advances in the Analysis of Hematologic Malignancies
Moderators:
Lina Shao, University of Michigan
Marilena Melas, Nationwide Children's Hospital
Characterization of atypical iAMP21 observed in B-Lymphoblastic Leukemia (B-ALL): a retrospective study from Mayo Clinic
Alaa Koleilat, Mayo Clinic
Tied for First Place Trainee Abstract Award
Complementarity of RNA sequencing and optical genome mapping in detection of rare fusions in pediatric B-ALL
Gordana Raca, Children's Hospital Los Angeles
Archer system copy number alteration caller: User experience
Celeste Eno, Cedars-Sinai Medical Center
Session Q & A
Platinum Vendor Showcase: Roche
(No CME available)
HyperPETE: A Novel Primer Extension Target Enrichment Solution for Rapid and Reliable Variant Detection Results
Brian Godwin, Roche Sequencing Solutions
From oncology to pathology and genomics and back again: A 360-degree perspective on a unique B-cell leukemia
Adrian Dubuc, Jacqueline Garcia, and Gabriel Griffin, Brigham and Women's Hospital
After Hours Social
Wednesday, August 4, 2021
Session 8: Hereditary Cancer/Cancer Predisposition
Moderators:
Xinjie Xu, Mayo Clinic
Angela Lager, University of Chicago
Large scale analysis in Von Hippel-Lindau disease
Kirsten Farncombe, University Health Network
Co-occurrence of rosette-forming glioneuronal tumors with Noonan syndrome
Marilena Melas, Nationwide Children's Hospital
10-year retrospective analysis of BRCA germline mutation in multiethnic gynecologic patients from a U.S. cancer center
Christina Wei, City of Hope National Medical Center
Identification of TP53 germline variants in pediatric patients undergoing tumor testing
Minjie Luo, The Children's Hospital of Philadelphia
Session Q & A
Gold Vendor Showcase: Oxford Nanopore
Break: Announcements
11:35 AM - 12:35 PM
Keynote Presentation
Proteogenomics as a driver for discovery of biomarkers and therapeutic targets in cancer
Kojo S. J. Elenitoba-Johnson, Penn Medicine’s Center for Personalized Diagnostics
Introduction: Yassmine Akkari, Legacy Health
Speaker Q & A
Diamond Vendor Showcase: Thermo Fisher Scientific
(No CME available)
Biomarker discovery through tumor profiling
Mary Napier, Thermo Fisher Scientific
Improved risk stratification for B-ALL patients using chromosome genomic array testing and targeted RNA sequencing
Min Fang, Fred Hutchinson Cancer Center Research Center and University of Washington, Seattle
Speaker Q & A
1:20 - 2:35 PM
Lunch Break / Exhibit Hall Open
Gold Vendor Showcase: BioDiscovery
(No CME available)
NxClinical's Approach to HRD Analysis
2:40 - 3:30 PM
Session 9: Updates from the CGC
Moderator:
Yassmine Akkari, Legacy Health
Launching a CGC initiative to support trainees and early career members: Survey results and analysis
Kilannin Krysiak, Washington University School of Medicine
Lindsey Byrne, The Ohio State University
Sheila Solomon, Guardant Health
The Compendium of Cancer Genome Aberrations (CCGA): Becoming a global hub for clinical interpretation
Jennelle Hodge, Indiana University
CGC PACC report: New initiatives and future directions
Rashmi Kanagal-Shamanna, MD Anderson Cancer Center
3:30 - 3:55 PM
Platinum Vendor Showcase: Oxford Gene Technology
(No CME available)
Transitioning CLL FISH analysis into the molecular biomarker era
Tracy Tucker, BC Cancer
Session 10: Bioinformatics: Applications and Developments
Moderator:
Obi Griffith, Washington University School of Medicine
A cost-effective bioinformatics triage strategy for testing PMS2 using short-read next generation sequencing
Wei Shen, Mayo Clinic
Computer-aided cytogenomic classification of renal cell carcinoma
Soheil Shams, BioDiscovery, Inc.
Session Q & A
Gold Vendor Showcase: Twist Bioscience
(No CME available)
Writing the future of cancer research
Melina Mathur, Twist Bioscience
4:30 - 5:30 PM
Exhibit Hall Open
5:30 - 6:30 PM
Session 11: Unraveling Solid Tumors with Genomic Technologies
Moderators:
Teresa Smolarek, Cincinnati Children's Hospital Medical Center
Niroshi Senaratne, University of California Los Angeles
Clinical utility and feasibility of adopting optical genome mapping for chromosomal characterization of solid tumors.
Nikhil Sahajpal, Augusta University
Second Place Technologist Abstract Award
Tumor cellularity estimation in a targeted NGS panel of tumor-only specimens expands analytical utility
Stephanie Siegmund, Brigham & Women's Hospital
A molecular and clinicopathologic analysis of primary intracranial sarcomas
Zahra Aldawood, Harvard School of Dental Medicine
Atypical FISH patterns clarified by RNAseq in solid tumor specimens
Beth Pitel, Mayo Clinic
Session Q & A
6:30 - 7:00 PM
CGC 2021 Business Meeting
Yassmine Akkari, CGC President, Legacy Health
Xinjie Xu, CGC Treasurer, Mayo Clinic
Patricia M. Miron, CGC President-Elect, UMass Memorial Medical Center
Meeting Q & A
Closing Remarks