Educational Resources


Cancer Genomics Consortium Educational Resources

Welcome to the Cancer Genomics Consortium’s Educational Resources page. Here, you will find comprehensive and up-to-date information aimed at enhancing the understanding and expertise in clinical cancer genomics. Our resources are designed for clinical and research professionals, offering insights into the latest in cancer genomics. 

NGS has been widely used to identify germline variants for diagnosing hereditary cancer syndromes. However, it may also detect mosaic variants that may be acquired due to clonal hematopoiesis of intermediate potential (CHIP). Which of the following cancer genes is most likely to be involved in CHIP?

A. TP53





According to the American College of Medical Genetics Laboratory Technical Standards and Guidelines, how long should images from neoplastic FISH cases be retained?

A. Two weeks after the report has been signed

B. Three years

C. Ten years

D. Twenty years


A female with a history of AML post transplant with a male donor has presented with the following karyotype. Which of the following is true based on the karyotypic abnormality?

A. Associated with a good prognosis for the patient

B. Auer rods are commonly present

C. Basophilia is commonly present

D. Monosomy 7 is a common secondary finding

male karotype; karotypic abnormality

The following CLL FISH panel result is from a 77 year old man referred due to an elevated white blood cell count. Based on the representative images, which statement is correct? 

A.This result is consistent with mantle cell lymphoma

B.This result is associated with a good prognosis in CLL

C.This result is not specific for CLL

D.This result is associated with the most adverse prognosis in CLL


During a surgical pathology rotation, you are asked to send a sample on a patient who might have a soft tissue tumor for cytogenetic G-band analysis. Which of these samples would you send to the lab? 

A. Blood

B.Fresh tissue

C.Frozen tissue

D.Formalin fixed tissue


What FISH panel would you order for myeloid neoplasms?

A. Chr. 5, 7, 8, 17, 20

B. Chr. 11, 12, 13, 17

C. Chr. 5, 11, 13, 17, 20

D. Chr. 1, 13, 14, 17


New B-lymphoblastic leukemia case: Based on genetics what result(s) has a very favorable prognosis?

A. t(4;11)(q21;q23)

B. t(12;21)(p13.2;q22.1)

C. Hypodiploid karyotype

D. t(9;22)(q34.1;q11.2)


A 4-year-old boy had bilateral lung cysts and cystic nephroma. A splicing variant was detected in a hereditary cancer NGS panel and tumor biopsy showed another frameshift variant in the same gene at 15%. What function is the gene involved?

A. DNA mismatch repair

B. Homologous recombination

C. RNA splicing

D. Gene silencing