2024 Scientific Program 

Download the CGC 2024 Scientific Agenda 

Sessions will be recorded and available for later viewing for our participants in different time zones.

In-Person Unconference

Unconference participation incurs an additional registration fee.

9:00 AM - 12:30 PM

In-Person VICC/CGC/CIViC/ClinGen Cancer Variant Curation and Coding Unconference

12:30 - 1:30 PM

Lunch for Unconference Attendees

1:30 - 2:30 PM

In-Person VICC/CGC/CIViC/ClinGen Cancer Variant Curation and Coding Unconference

2:30 - 3:00 PM

Coffee Break for Unconference Attendees

3:00 - 5:00 PM

In-Person VICC/CGC/CIViC/ClinGen Cancer Variant Curation and Coding Unconference

6:30 - 8:30 PM

Evening Social for Unconference Attendees
The Rooftop 360 at Hilton St. Louis at the Ballpark

Pre-Meeting Workshops

Workshop participation incurs an additional registration fee, which includes attendance at both sessions.

9:00 - 10:30 AM

Leadership Workshop

Moderators: Xiaoyu Qu, Fred Hutchinson Cancer Center and Teresa Smolarek, Cincinnati Children's Hospital Medical Center

Presenter:
Michael Johnson, University of Washington

Coffee Break for Workshop Attendees

10:45 AM - 12:15 PM

Bioinformatics Workshop

Moderator: Alex Wagner, Nationwide Children's Hospital and the Ohio State University

Presenters:
Malachi Griffith, Washington University in St. Louis School of Medicine 
Alan Rubin, Walter and Eliza Hall Institute 
Sumaiya Iqbal, Broad Institute 

Opening of the 15th Annual Cancer Genomics Consortium

1:00 - 1:05 PM

Welcome
Jane Houldsworth, Icahn School of Medicine at Mount Sinai

1:05 - 1:15 PM

Presidential Address
Rashmi Kanagal-Shamanna, MD Anderson Cancer Center

1:15 - 2:15 PM

Keynote Presentation
Enabling clinical translation of high-throughput functional assay data
Alan Rubin, Walter and Eliza Hall Institute
Introduction: Wesley Goar, Nationwide Children's Hospital

2:15 - 3:00 PM

Speed Abstracts Session I: Precisive genetic diagnosis of hematological and other malignancies

Enrichment of Hodgkin and Reed-Sternberg (HRS) cells using size-based microfiltration
Brianna Munnich, Washington University in St. Louis School of Medicine
Technologist Award

Diagnostic next generation sequencing to detect MYD88 L265P in lymphoplasmacytic lymphoma compared to ddPCR
Lauren Wainman, Dartmouth-Hitchcock Medical Center

Interplatform comparison of Stratys and Saphyr: Preliminary results of OGM clinical verification in hematologic cancers
Eric McGinnis, Vancouver General Hospital

The clinical implementation of technologies utilized for macrogenomic event detection in solid tumors
Lisa Lansdon, Children's Mercy Kansas City & UMKC - School of Medicine

Implementation of automatic slide processing for aneuploidy FISH test
Wenhua Zhou, ARUP Laboratories 

3:00 - 3:30 PM

Exhibitor Showcase: Illumina
(No CME or CEUs available)

3:30 - 4:15 PM

Coffee Break in the Exhibit Hall

Science Café Presentations

10x Genomics
Leilani Marty-Santos, 10x Genomics

Roche Diagnostics & Life Science
Dustin Masser, Roche Sequencing and Life Science

Labcorp
Tom LeRoux, Labcorp Oncology

Session 1: Diagnostic and prognostic impact of molecular profiling across hematological neoplasms

Hot-spot D816 KIT has different clinical outcome compared to non-D816 KIT variants in myeloid neoplasms
Barina Aqil, Northwestern University Feinberg School of Medicine

Implementation and utility of gene expression profile (GEP)-based classification of pediatric B-lymphoblastic leukemia
Gordana Raca, Children's Hospital Los Angeles

Reduced subclone diversity in clonal cytopenia of undetermined significance compared to myelodysplastic syndrome
Sridhar Nonavinkere Srivatsan, Washington University School of Medicine in St Louis

Best practices for testing and reporting of FISH studies in multiple myeloma: recommendations from the CGC working group
Xinyan Lu, Northwestern University Feinberg School of Medicine

5:15 - 5:45 PM

Speed Abstracts Session II: Standardization, bioinformatics workflows, and data integration for personalized healthcare

Standardizing fusion calls in a computable format with FUSOR for downstream clinical assessment
Jeremy Arbesfeld, The Ohio State University

Developing a robust bioinformatics workflow to support personalized neoantigen vaccine clinical trials
Kartik Singhal, Washington University in St Louis

Contextualizing clinical significance using FDA label supplemented DGI data
Matthew Cannon, Nationwide Children's Hospital
Trainee Award

AmpliconSuite: Analyzing focal amplifications in cancer genomes
Bhargavi Dameracharla, University of California, San Diego

5:45 - 6:15 PM

CGC 2024 Business Meeting

6:15 - 8:00 PM

Welcome Reception and Celebration of the CGC 15th Anniversary
CGC Exhibit Hall, Grand Ballroom ABCD

Keynote Presentation
The Grand Challenge of Cancer Disparities
Melissa B. Davis, Morehouse School of Medicine
Introduction: Thuy Phung, University of South Alabama

Session 2: Genomic equity and inclusivity: Bridging the gap in diagnostics and personalized care across diverse populations

Ethnic and molecular disparities in prostate adenocarcinoma incidence: Data from 19 cohort studies
Amy Brady, SUNY Upstate Medical University
Trainee Award

Clinical impact of in-house molecular testing for underserved cancer patients in southern Alabama
Thuy Phung, University of South Alabama

An evaluation of clinical significance of the TP53 polyadenylation signal-disrupting variant rs78378222-G
Dayo Shittu, National Institute of Health/National Human Genome Research Institute

10:15 - 10:45 AM

Panel Discussion on genomic equity and inclusivity: Bridging the gap in diagnostics and personalized care across diverse populations

Panelists:
Amy Brady, SUNY Upstate Medical University
Melissa B. Davis, Morehouse School of Medicine
Thuy Phung, University of South Alabama
Dayo Shittu, NIH / National Human Genome Research Institute

10:45 - 11:30 AM

Coffee Break in the Exhibit Hall

Science Café Presentations

Phase Genomics
Stephen Eacker, Phase Genomics

Oxford Nanopore Technologies
Ellie Suarez, Oxford Nanopore Technologies

STEMCELL Technologies
Andrew Trembath, STEMCELL Technologies Inc.

11:30 AM - 12:00 PM

Diamond Exhibitor Showcase: Guardant
Liquid Biopsy in Cancer Care: Current Applications and Future Signatures
Jill Tsai, Guardant Health
(No CME or CEUs available)

Invited Speaker Presentation
Current and Future Integrations of Genomics and AI
Chad Vanderbilt, Memorial Sloan Kettering Cancer Center
Introduction: Chuan Gao, Memorial Sloan Kettering Cancer Center

Speed Abstracts Session III: Integrated sample processing and genomic analysis approaches that improve diagnostic yield for hematologic malignancies

Intrachromosomal amplification of chromosome 21 as the sole chromosomal aberration in a primary AML patient
Leila Youssefian, University of California, Los Angeles

Tumor specific cell sorting improves sensitivity of FISH: implications for patients with hematologic malignancies
Luise Hartmann, Hematologics Inc.

High resolution cytogenomic analysis reveals characterizing abnormalities in APL-like leukemia
Shivaprasad Sathyanarayana, Dartmouth Hitchcock Medical Center

FIP1L1::KIT fusion in a case of peripheral T-cell lymphoproliferative neoplasm responsive to tyrosine kinase inhibitor
Kristin Deeb, Emory University

1:00 - 1:15 PM

CGC Updates
Rashmi Kanagal-Shamanna, MD Anderson Cancer Center
(No CME or CEUs available)

1:15 - 2:15 PM

Buffet Lunch in the Exhibit Hall
Exhibit Hall and Foyer

2:15 - 3:15 PM

Session 3: Advances in molecular profiling for tumor risk assessment and management 

Methylation profiling more accurately predicts recurrence risk in meningiomas compared to current WHO grading criteria
Lucas Santana dos Santos, Northwestern University

Advancing personalized prostate cancer care: Utilizing miRNA profiling and machine learning for metastasis prediction
Gobi Thillainadesan, Sunnybrook Research Institute

Detection of somatic tumor mutations in circulating plasma DNA of patients with sellar and skull
base tumors
Mallory Tucker, University of Washington

Methylation sequencing enhances interpretation of clonal hematopoiesis dynamics
Alyssa Parker, Vanderbilt University
Trainee Award

3:15 - 3:45 PM

Panel Discussion on advances in molecular profiling for tumor risk assessment and management 

Panelists:
Alyssa Parker, Vanderbilt University
Robert Sebra, Icahn School of Medicine at Mount Sinai
Gobi Thillainadesan, Sunnybrook Research Institute
Mallory Tucker, University of Washington
Chad Vanderbilt, Memorial Sloan Kettering Cancer Center

3:45 - 4:00 PM

Exhibitor Showcase: Bionano
Improving sensitivity and workflow efficiency in myeloid malignancy research with optical genome mapping: A multi-institutional study
(No CME or CEUs available)

4:00 - 4:15 PM

Exhibitor Showcase: Natera
Personalized MRD assessment to inform treatment decisions in patients with solid tumor cancers
Tanner Hagelstrom, Natera, Inc.
(No CME or CEUs available)

4:15 - 5:00 PM

Coffee Break in the Exhibit Hall

Science Café Presentations

nRichDX
Nafiseh Jafari, nRichDX

SOPHiA Genetics
Tyler Matheny, SOPHiA GENETICS

Invited Speaker Presentation
Interpretable and context-free deconvolution of multi-scale transcriptomic lung cancer data
Robert Sebra, Icahn School of Medicine at Mount Sinai
Introduction: Huan Mo, NHGRI

5:30 - 6:30 PM

Session 4: Global initiatives in enhancing interpretation of the somatic genome

Enhancing precision oncology: the value of open-source knowledgebase integration
Cameron Grisdale, Canada's Michael Smith Genome Sciences Centre

Classifying the oncogenicity of 100 variants from pediatric cancer patients using a standardized assessment framework
Wesley Goar, Nationwide Children's Hospital

Somatic genomic testing and variant curation practices in Australian and New Zealand diagnostic testing laboratories
Grace Pendlebury, Australian Genomics & QIMRB Berghofer

Addition of non-gene features to the CIViC data model
Arpad Danos, Washington University in St. Louis

6:30 - 8:00 PM

Early Career Social
For attendees in training or recently out of training
Park View Room, Fourth Floor

Invited Speaker Presentation
TBA pending FDA approval

Introduction: Yassmine Akkari, Nationwide Children's Hospital 

Invited Speaker Presentation
To a carpenter, every problem is a nail: The FDA brings a hammer to diagnostic medicine 
Dara Aisner, University of Colorado Anschutz Medical Campus
Introduction: Fady Mikhail, University of Alabama at Birmingham

Session 5: Development of resources for the reimbursement and clinical reporting standardization of cancer genomic testing

Moderators: Fady Mikhail, University of Alabama at Birmingham and Niroshi Senaratne, University of California Los Angeles

Reimbursement for molecular pathology testing for neoplasia: The 2024 update
Xiaoyu Qu, Fred Hutchinson Cancer Center

Current next generation sequencing reporting practices: a GOAL consortium report
Celeste Eno, Cedars-Sinai Medical Center

A cross-consortia initiative for aligning the definitions and descriptions of gene fusions
Alex Wagner, Nationwide Children's Hospital

Panel Discussion on Development of resources for the reimbursement and clinical reporting standardization of cancer genomic testing
Moderator: Yassmine Akkari, Nationwide Children's Hospital

Panelists:
Dara Aisner, University of Colorado Anschutz Medical Campus
Celeste Eno, Cedars-Sinai Medical Center
Xiaoyu Qu, Fred Hutchinson Cancer Center
Alex Wagner, Nationwide Children's Hospital and the Ohio State University

10:45 - 11:30 AM

Coffee Break in the Exhibit Hall

Science Cafe Presentations

AstraZeneca
Medical Science Liaison, AstraZeneca

Integrated DNA Technologies
Brett Reed, Integrated DNA Technologies

Velsera
Andrew Bredemeyer, Velsera

11:30 - 11:45 AM

Platinum Exhibitor Showcase: QIAGEN
Expert perspectives on the challenges and opportunities of implementing comprehensive genomic profiling
Ravindra Kolhe, Medical College of Georgia, Augusta University
(No CME or CEUs available)

11:45 AM - 12:00 PM

Exhibitor Showcase: Novartis
Early Breast Cancer: Biomarker Testing and Assessing Risk of Recurrence
Roger Bishop, Novartis Personalized and Precision Medicine
(No CME or CEUs available)

Invited Speaker Presentation
Cell-free DNA and AI technology for liquid biopsy detection of cancer early and prediction of cancer treatment response
Aadel Chaudhuri, Mayo Clinic
Introduction: Trevor Pugh, University of Toronto

12:30 - 1:45 PM

In-Person Round Table Discussions with Lunch
Please sign up for table topics during meeting registration.
Hyatt Regency, Fourth Floor Foyer and Mills Meeting Rooms

1:00 - 1:45 PM

Virtual Ask-Me-Anything Discussions
Accessible from the Virtual Platform

Learn More About the Cancer Genomics Consortium (CGC)
Obi Griffith, CGC Past President, Washington University School of Medicine in St. Louis
Rebecca Smith, CGC Volunteer and Early Career Committee Chair, Vanderbilt University Medical Center
Karla Gay, CGC Executive Director

Learn More About the Compendium of Cancer Genome Aberrations (CCGA)
Jennelle Hodge, Indiana University School of Medicine

Learn More About Commercial vs. Academic Workspaces
Alka Chaubey, Bionano
Honey Reddi, Belay Diagnostics

2:00 - 2:30 PM

Speed Abstracts Session IV: Innovative tools and challenges in genetic variant analysis

pVACsplice: A computational tool for predicting and prioritizing alternative splicing neoantigens
My Hoang, Washington University School of Medicine in St. Louis

Customize your variant interpretation workflow with OpenCRAVAT
Rachel Karchin, Johns Hopkins University

Identifying challenges in variant normalization
Anastasia Bratulin, The Ohio State University

2:30 - 2:45 PM

Exhibitor Showcase: Thermo Fisher Scientific
Chromosomal microarray analysis to the rescue: Diagnosis of challenging intracranial tumors
Madina Sukhanova, Northwestern University Feinberg School of Medicine
(No CME or CEUs available)

Coffee Break in the Exhibit Hall

Science Café Presentations

Bioview
Elad Kfir, BioView, Ltd.

Invivoscribe, Inc.
Tony Sanchez, Invivoscribe, Inc.

Keynote Presentation
Precision interception in multiple myeloma and it’s precursor conditions
Irene Ghobrial, Dana Farber Cancer Institute
Introduction: Linda Baughn, Mayo Clinic

4:30 - 6:00 PM

Poster Session
CGC Exhibit Hall, Grand Ballroom ABCD

St. Louis Riverboat Cruise:
Meet at 5:30 PM in the Hyatt Regency Lobby to walk to the river entrance on the far side of the arch. Boat loads at 5:45 PM and departs promptly at 6:00 PM. Cruise is one hour in length.

St. Louis Cardinals vs. Tampa Bay Rays:
Meet at 6:00 PM in the Hyatt Regency Lobby to walk to the event together or join the group at Busch Stadium. Game starts at 6:45 PM.

Bowling:
Meet at 6:00 PM in the Hyatt Regency Lobby to get to the event together or meet the group at Flamingo Bowl. Reservations at 6:30pm.

Session 6: Genomic analyses of solid tumors: Arrays, sequencing and developing a gene list

Integrated comprehensive genomic profiling of meningiomas: A single institutional study
Mohana Priya Jayavel, Northwestern Memorial Hospital
Technologist Award

Significant copy number variants and loss of heterozygosity in Wilms Tumor: Insights from Nationwide Pediatric Oncology
Melanie Babcock, Nationwide Children's Hospital and The Ohio State University

The clinical utility of the TSO500 clinically-verified test in patients with solid tumors - The Mayo Clinic experience
Hussam Al Kateb, Mayo Clinic 

Formation of a tumor-specific gene list: the Central Nervous System (CNS) tumor taskforce experience
Madina Sukhanova, Feinberg School of Medicine Northwestern University

Session 7: Updates in oncogenicity guidelines and classification rules for prioritizing variants in somatic disease

Modifying cancer variant interpretation guidelines for the curation of histone H3 variants - the 'next step' of the Cl
Laveniya Satgunaseelan, Royal Prince Alfred Hospital

Prioritization of defining and supportive diagnostic variants in pediatric tumors
Laura Corson, Oncology Consultant

Step 2 updates for the Oncogenic assessment of FLT3 Variants by the ClinGen FLT3 Somatic Cancer Variant Curation expert
Nathan Kopp, Medical College of Wisconsin

Piloting NTRK fusion-specific oncogenicity guidelines: Lessons learned
Jason Saliba, Washington University School of Medicine

11:00 - 11:30 AM

Coffee Break in the Exhibit Hall

Session 8: Advancements in cancer-adjacent genetic diagnostics: Guidelines, assays, and case studies

Challenges of classifying variants associated with disorders of somatic mosaicism and guideline creation
Alexa Dickson, Washington University in St Louis

UMI-based expanded NGS panel in precision molecular diagnosis of vascular anomalies: Early results
Avinash Dharmadhikari, Children's Hospital Los Angeles

Examining potential candidate genes within deletions of 3p14.2 to 3p14.1 in two cases of autism and developmental delay
Rebecca Smith, Vanderbilt University Medical Center

Clinical SNP-array adds value to diagnosis and surveillance of bone marrow failure syndromes
Lucilla Pizzo, University of Utah, ARUP Laboratories